fig serum igg titers in groups и = for particles, n = for soluble of balbc mice immunized with either plgctabp gag dna of acyclovir and birth control size nm or in or dna alone at two dose levels of xg and xg antibody titers are geometric mean titers ± se at weeks acyclovir and birth control postsecond immunization week time point after immunizations at day and day the response from the nm and xm particles at both dose levels are not significantly different an important component of the adjuvant effect, since larger microparticles xm did not elicit a strong immune response the association of dna with nanoparticles acyclovir and birth control and microparticles has been shown to be more effective than naked dna chitosandna particles nm of peanut allergen gene delivered orally, produced secretory iga and acyclovir and birth control serum igga, compared with no detectable response with naked dna the pulmonary delivery of chitosandna particles average size of nm with plasmid dna encoding tcell acyclovir and birth control epitopes from mycobacterium tuberculosis, were able to induce the maturation of dendritic cells and the increased level of ifny secretion, compared with the plasmid in solution acyclovir and birth control or im delivery in another dna study, polylysinegraft imidazoleacetic acid complexed with dna with a diameter of nm was used for the hiv env plasmid acyclovir and birth control it was found that igg, igm and iga responses were increased several folds, compared with naked dna it was also speculated that this formulation may also help protect the dna from nuclease degradation based on the evidence in the literature, the rationale for preparing nanoparticles rather than the more established microparticles acyclovir and birth control is not necessarily clear with the dna formulations conclusions a number of systems with different types of antigen proteins, peptides, dna have been investigated with acyclovir and birth control the particles ranging in size from nm to nm for most systems, the critical particle size is zm, with particles in the range of nm acyclovir and birth control to zm, often inducing comparable immune responses in some cases, depending on the route of delivery, there may be increased immune responses with the smaller acyclovir and birth control nanoparticles for in administration, there was no evidence that nm particles were better than micron particles for oral administration, some studies found enhanced responses with nanoparticles, acyclovir and birth control compared with microparticles, while other studies found equivalence, or that microparticles elicited higher responses overall, the evidence for nanoparticles nm outperforming microparticles zm for enhanced acyclovir and birth control immunogenicity is weak further examination is needed to support nanoparticles as a better formulation in place of microparticles also, some of the studies carried out were done model antigens and the same results maymay not apply to relevant antigens where vaccine efficacy is determined however, there are some advantages to nanoparticles acyclovir and birth control compared with microparticles that have not been directly addressed for instance, smaller nanoparticles sub nm can be sterile filtered, allowing the particle preparation to be acyclovir and birth control a nonsterile process with terminal sterilization the distinction between nanoparticles and microparticles is usually made by the authors and there is no consistency in what acyclovir and birth control constitutes a nanoparticle, and this needs careful consideration when comparing results from the literature the important size measurement point is immediately prior to administration, post lyophilization, acyclovir and birth control or other processing, and this is not always reported more relevant endpoints such as protective efficacy may be crucial in distinguishing between nanoparticles and microparticles acyclovir and birth control nanoparticles and microparticles both constitute a very effective vaccine delivery system some of these formulations are currently in preclinical and clinical evaluations acknowledgments we would acyclovir and birth control like to acknowledge the contributions of our colleagues in chiron corporation to the ideas contained in the chapter, particularly, all the members of the vaccine acyclovir and birth control adjuvants and delivery group references gupta rk and siber gr adjuvants for human vaccinescurrent status, problems and future prospects vaccine gupta rk, griffin p, jr, chang acyclovir and birth control ac, rivera r, anderson r, rost b, cecchini d, nicholson m and siber gr the role of adjuvants and delivery systems in modulation of immune acyclovir and birth control response to vaccines adv exp med biol ramon g sur la toxine et surranatoxine diphtheriques ann inst pasteur vogel fr and powell mf a compendium acyclovir and birth control of vaccine adjuvants and excipients pharm biotechnol gupta rk aluminum compounds as vaccine adjuvants adv drug deliv rev relyveld eh, bizzini в and gupta rk rational acyclovir and birth control approaches to reduce adverse reactions in man to vaccines containing tetanus and diphtheria toxoids vaccine gupta rk, chang ac, griffin p, rivera r and siber acyclovir and birth control gr in vivo distribution of radioactivity in mice after injection of biodegradable polymer microspheres containing clabeled tetanus toxoid vaccine ulanova m, tarkowski a, hahnzoric m acyclovir and birth control and hanson la the common vaccine adjuvant aluminum hydroxide upregulates accessory properties of human monocytes via an interleukindependent mechanism infect immun shi y, hogenesch h, regnier acyclovir and birth control fe and hem sl detoxification of endotoxin by aluminum hydroxide adjuvant vaccine edelman r new generation vaccines adjuvants for the future, in levine gcw, mm, acyclovir and birth control kaper jb and cobon gs eds marcel dekker, inc, new york, pp zinkernagel rm, ehl s, aichele p, oehen s, kundig t and hengartner h acyclovir and birth control antigen localization regulates immune responses in a dose and timedependent fashion a geographical view of immune reactivity immunol rev fearon dt seeking wisdom in innate acyclovir and birth control immunity nature fearon dt and locksley rm the instructive role of innate immunity in the acquired immune response science yip hc, karulin ay, tarylehmann m, hesse acyclovir and birth control md, radeke h, heeger ps, trezza rp, heinzel fp, forsthuber t and lehmann pv adjuvantguided type and type immunity infectiousnoninfectious dichotomy defines the class of acyclovir and birth control response f immunol kreuter j and speiser pp new adjuvants on a polymethylmethacrylate base infect immun eldridge jh, staas jk, meulbroek ja, tice tr and acyclovir and birth control gilley rm biodegradable and biocompatible poly dllactidecoglycolide microspheres as an adjuvant for staphylococcal enterotoxin в toxoid which enhances the level of toxinneutralizing antibodies infect immun ohagan acyclovir and birth control dt, jeffery h and davis ss longterm antibody responses in mice following subcutaneous immunization with ovalbumin entrapped in biodegradable microparticles vaccine nakaoka r, inoue y, acyclovir and birth control tabata y and ikada y size effect on the antibody production induced by biodegradable microspheres containing antigen vaccine tabata y, inoue y and ikada y acyclovir and birth control size effect on systemic and mucosal immune responses induced by oral administration of biodegradable microspheres vaccine quintanarguerrero d, allemann e, fessi h and doelker e preparation acyclovir and birth control techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers drug dev ind pharm vajdy m and ohagan dt microparticles for intranasal immunization adv acyclovir and birth control drug del rev singh m and ohagan d the preparation and characterization of polymeric antigen delivery systems for oral administration blind viagra adv drug del rev cui acyclovir and birth control z and mumper rj microparticles and nanoparticles as delivery systems for dna vaccines crit rev ther drug can syst gupta rk, singh m and ohagan acyclovir and birth control dt polylactidecoglycolide microparticles for the development of singledose controlledrelease vaccines adv drug del rev tamber h, johansen p, merkle hp and gander в formulation aspects of biodegradable polymeric microspheres for antigen delivery adv drug del rev panyam j and labhasetwar v biodegradable nanoparticles for drug and gene delivery to cells and acyclovir and birth control tissue adv drug del rev degen wg, jansen t and schijns ve vaccine adjuvant technology from mechanistic concepts to practical applications expert rev vaccines schijns ve immunological concepts of vaccine adjuvant activity commentary cur opin immun scholes pd, coombes aga, ilium l, daviz ss, vert m and davies mc the preparation acyclovir 10 500 lortab and birth control of sub nm poly lactidecoglycolide microspheres for sitespecific drug delivery ] control rel blanco md and alonso mj development and characterization of proteinloaded polylactidecoglycolide nanospheres acyclovir and birth control eur j pharm biopharm nguyen xc, herberger jd and burke pa protein powders for encapsulation a comparison of sprayfreeze drying and spray drying of darbepoetin acyclovir and birth control alfa pharm res thomasin c, merkle hp and gander в drug microencapsulation by plaplga coacervation in the light of thermodynamics parameters determining microsphere formation j pharm sci thomasin с, ho nt, merkle hp and gander в drug microencapsulation by plaplga coacervation in the light of thermodynamics overview and theoretical considerations } acyclovir and birth control pharm sci cleland jl and jones aj stable formulations of recombinant human growth hormone and interferongamma for microencapsulation in biodegradable microspheres pharm res singh m, kazzaz j, chesko j, soenawan e, ugozzoli m, giuliani m, pizza m, rappouli r and ohagan dt anionic microparticles are a potent delivery system for acyclovir and birth control recombinant antigens from neisseria meningitidis serotype b j pharm sci jung t, kamm w, breitenbach a, hungerer kd, hundt e and kissel t tetanus toxoid loaded acyclovir and birth control nanoparticles from sulfobutylated polyvinyl alcoholgraftpolylactide coglycolide evaluation of antibody response after oral and nasal application in mice pharm res kazzaz j, neidleman j, singh m, acyclovir and birth control ott g and ohagan dt novel anionic microparticles are a potent adjuvant for the induction of cytotoxic t lymphocytes against recombinant p gag from hiv acyclovir and birth control } control rel fessi h, puisieux f, devissaguet jp, ammoury n and benita s nanocapsule formation by interfacial polymer deposition following solvent displacement int } pharm acyclovir and birth control rr fessi h, puisieux f and devissaguet jp process for the preparation of dispersible colloidal systems of a substance in the form of nanocapsules eur patent peltonen l, koistinen p, karjalainen m, hakkinen a and hirvonen j the effect of cosolvents on the formulation of nanoparticles from lowmolecularweight polyllactide aaps pharm sci tech e wehrle p, magenheim в and benita s the influence of process parameters on the pla nanoparticle size distribution, evaluated by means of acyclovir and birth control factorial design eur } pharm biopharm niwa t, takeuchi h, hino t, kunou n and kawashima y preparations of biodegradable nanospheres of watersoluble and insoluble acyclovir and birth control drugs with — lactide glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior j control rel molpeceres j, guzman acyclovir and birth control m, aberturas mr, chacon m and berges l application of central composite designs to the preparation of polycaprolactone nanoparticles by solvent displacement } pharm sci acyclovir and birth control calvo p, remunanlopez c, vilajato jl and alonso mj development of positively charged colloidal drug carriers chitosan coated polyester nanocapsules and submicron emulsions coll polym sci acyclovir and birth control jung t, breitenbach a and kissel t sulfobutylated polyvinyl alcoholgraft polylactidecoglycolides facilitate the preparation of small negatively charged biodegradable nanospheres control rel ohagan dt, palin acyclovir and birth control kj and davis ss polybutylcyanoacrylate particles as adjuvants for oral immunization vaccine chauvierre c, labarre d, couvreur p and vauthier с novel polysaccharide decorated polyisobutyl cyanoacrylate nanoparticles pharm res major m, prieur e, tocanne jf, betbeder d and sautereau am characterization and phase behaviour of phospholipid bilayers adsorbed on spherical polysaccharidic acyclovir and birth control nanoparticles biochim biophys acta baudner вс, balland o, giuliani mm, von hoegen p, rappuoli r, betbeder d and del giudice g enhancement of protective efficacy acyclovir and birth control following intranasal immunization with vaccine plus a nontoxic ltk mutant delivered with nanoparticles infect immun singla ak and chawla m chitosan some pharmaceutical and biological acyclovir and birth control aspects an update} pharm pharmacol mcneela ea, jabbalgill i, ilium l, pizza m, rappuoli r, podda a, lewis djm and mills khg intranasal immunization with genetically acyclovir and birth control detoxified diphtheria toxin induces t cell responses in humans enhancement of th responses and toxin neutralizing antibodies by formulation with chitosan vaccine nagamoto t, hattori acyclovir and birth control y, takayama к and maitani y novel chitosan particles and chitosancoated emulsions inducing immune response via intranasal vaccine delivery pharm res vila a, sanchez a, acyclovir and birth control tobio m, calvo p and alonso mj design of biodegradable particles for protein delivery j control rel ilium l, jabbalgill i, hinchcliffe m, fisher an acyclovir and birth control and davis ss chitosan as a novel nasal delivery system for vaccines adv drug del rev pantarotto d, partidos cd, hoebeke j, brown f, kramer e, acyclovir and birth control briand jp, muller s, prato m and bianco a immunization with peptidefunctionalized carbon nanotubes enhances virusspecific neutralizing antibody responses chem biol cui z and mumper acyclovir and birth control rj coating of cationized protein on engineered nanoparticles results in enhanced immune responses int j pharm he q, mitchell a, morcol t and bell sj acyclovir and birth control calcium phosphate nanoparticles induce mucosal immunity and protection against herpes simplex virus type clin diagn lab immunol bisht s, bhakta g, mitra s and maitra a acyclovir and birth control pdna loaded calcium phosphate nanoparticles highly efficient nonviral vector for gene delivery int j pharm ohagan dt novel delivery systems for oral vaccines microparticles as oral vaccines ohagan dt, editor crc press, boca raton ohagan dt, ott gs and van nest g recent advances in vaccine adjuvants the development of acyclovir and birth control mf emulsion and polymeric microparticles mol med today moore a, mcguirk p, adams s, jones wc, mcgee jp, ohagan dt and mills kh immunization with a acyclovir and birth control soluble recombinant hiv protein entrapped in biodegradable microparticles induces hivspecific cd cytotoxic t lymphocytes and cd thl cells vaccine maloy kj, donachie am, ohagan dt and mowat am induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in polylactidecoglycolide microparticles immunology nixon df, hioe c, chen pd, acyclovir and birth control bian z, kuebler p, li ml, qiu h, li xm, singh m, richardson j, mcgee p, zamb t, koff w, wang cy and ohagan d synthetic peptides entrapped in microparticles can elicit cytotoxic t cell activity vaccine vordermeier hm, coombes ag, jenkins p, mcgee jp, ohagan dt, davis ss and singh m synthetic delivery system for tuberculosis vaccines immunological evaluation of the m tuberculosis kda protein entrapped in biodegradable plg microparticles vaccine kovacsovicsbankowski m and rock acyclovir and birth control kl a phagosometocytosol pathway for exogenous antigens presented on mhc class i molecules science scheicher c, mehlig m, dienes hp and reske к uptake of microparticleadsorbed protein antigen by bone marrowderived dendritic cells results in upregulation of interleukin alpha and interleukin pp and triggers prolonged, efficient antigen presentation eur j immunol acyclovir and birth control brayden dj and baird aw microparticle vaccine approaches to stimulate mucosal immunisation microbes infect florence at the oral absorption of micro and nanoparticulates neither exceptional acyclovir and birth control nor unusual pharm res vila a, sanchez a, janes k, behrens i, kissel t, jato jlv and alonso mj low molecular weight chitosan nanoparticles as acyclovir and birth control new carriers for nasal vaccine delivery in mice eur j pharm biopharm debin a, kravtzoff r, santiago jv, cazales l, sperandio s, melber k, janowicz z, betbeder d and moynier m intranasal immunization with recombinant antigens associated with new cationic particles induces strong mucosal as well as systemic antibody and ctl acyclovir and birth control responses vaccine gutierro i, hernandez rm, igartua m, gascon ar and pedraz jl size dependent immune response after subcutaneous, oral and intranasal administration of bsa acyclovir and birth control loaded nanospheres vaccine vila a, sanchez a, evora c, soriano i, lato jlv and alonso mj pegpla nanoparticles as carriers for nasal vaccine delivery j acyclovir and birth control aerosol med diwan m, tafaghodi m and samuel j enhancement of immune responses by codelivery of a cpg oligodeoxynucleotide and tetanus toxoid in biodegradable nanospheres control acyclovir and birth control rel lam cw, james jt, mccluskey r and hunter rl pulmonary toxicity of single wall carbon nanotubes in mice and days after intratracheal instillation toxicol sci jia g, wang hf, yan l, wang x, pei rj, yan t, zhao yl and guo xb cytotoxicity of carbon nanomaterials singlewall nanotube, multiwall acyclovir and birth control nanotube, and fullerene environ sci tech katare yk, panda ak, lalwani k, haque iu and ali mm potentiation of immune response from polymerentrapped antigen toward development acyclovir and birth control of single dose tetanus toxoid vaccine drug del johnson ol, cleland jl, lee hj, charnis m, duenas e, jaworowicz w, shepard d, shahzamani a, jones acyclovir and birth control aj and putney sd a monthlong effect from a single injection of microencapsulated human growth hormone nat med thiele l, rothenrutishauser b, jilek s, wunderliallenspach acyclovir and birth control h, merkle hp and walter e evaluation of particle uptake in human blood monocytederived cells in vitro does phagocytosis activity of dendritic cells measure up with macrophages?
fig serum igg titers in groups и = for particles, n = for soluble of balbc mice immunized with either plgctabp gag dna of acyclovir and birth control size nm or in or dna alone at two dose levels of xg and xg antibody titers are geometric mean titers ± se at weeks acyclovir and birth control postsecond immunization week time point after immunizations at day and day the response from the nm and xm particles at both dose levels are not significantly different an important component of the adjuvant effect, since larger microparticles xm did not elicit a strong immune response the association of dna with nanoparticles acyclovir and birth control and microparticles has been shown to be more effective than naked dna chitosandna particles nm of peanut allergen gene delivered orally, produced secretory iga and acyclovir and birth control serum igga, compared with no detectable response with naked dna the pulmonary delivery of chitosandna particles average size of nm with plasmid dna encoding tcell acyclovir and birth control epitopes from mycobacterium tuberculosis, were able to induce the maturation of dendritic cells and the increased level of ifny secretion, compared with the plasmid in solution acyclovir and birth control or im delivery in another dna study, polylysinegraft imidazoleacetic acid complexed with dna with a diameter of nm was used for the hiv env plasmid acyclovir and birth control it was found that igg, igm and iga responses were increased several folds, compared with naked dna it was also speculated that this formulation may also help protect the dna from nuclease degradation based on the evidence in the literature, the rationale for preparing nanoparticles rather than the more established microparticles acyclovir and birth control is not necessarily clear with the dna formulations conclusions a number of systems with different types of antigen proteins, peptides, dna have been investigated with acyclovir and birth control the particles ranging in size from nm to nm for most systems, the critical particle size is zm, with particles in the range of nm acyclovir and birth control to zm, often inducing comparable immune responses in some cases, depending on the route of delivery, there may be increased immune responses with the smaller acyclovir and birth control nanoparticles for in administration, there was no evidence that nm particles were better than micron particles for oral administration, some studies found enhanced responses with nanoparticles, acyclovir and birth control compared with microparticles, while other studies found equivalence, or that microparticles elicited higher responses overall, the evidence for nanoparticles nm outperforming microparticles zm for enhanced acyclovir and birth control immunogenicity is weak further examination is needed to support nanoparticles as a better formulation in place of microparticles also, some of the studies carried out were done model antigens and the same results maymay not apply to relevant antigens where vaccine efficacy is determined however, there are some advantages to nanoparticles acyclovir and birth control compared with microparticles that have not been directly addressed for instance, smaller nanoparticles sub nm can be sterile filtered, allowing the particle preparation to be acyclovir and birth control a nonsterile process with terminal sterilization the distinction between nanoparticles and microparticles is usually made by the authors and there is no consistency in what acyclovir and birth control constitutes a nanoparticle, and this needs careful consideration when comparing results from the literature the important size measurement point is immediately prior to administration, post lyophilization, acyclovir and birth control or other processing, and this is not always reported more relevant endpoints such as protective efficacy may be crucial in distinguishing between nanoparticles and microparticles acyclovir and birth control nanoparticles and microparticles both constitute a very effective vaccine delivery system some of these formulations are currently in preclinical and clinical evaluations acknowledgments we would acyclovir and birth control like to acknowledge the contributions of our colleagues in chiron corporation to the ideas contained in the chapter, particularly, all the members of the vaccine acyclovir and birth control adjuvants and delivery group references gupta rk and siber gr adjuvants for human vaccinescurrent status, problems and future prospects vaccine gupta rk, griffin p, jr, chang acyclovir and birth control ac, rivera r, anderson r, rost b, cecchini d, nicholson m and siber gr the role of adjuvants and delivery systems in modulation of immune acyclovir and birth control response to vaccines adv exp med biol ramon g sur la toxine et surranatoxine diphtheriques ann inst pasteur vogel fr and powell mf a compendium acyclovir and birth control of vaccine adjuvants and excipients pharm biotechnol gupta rk aluminum compounds as vaccine adjuvants adv drug deliv rev relyveld eh, bizzini в and gupta rk rational acyclovir and birth control approaches to reduce adverse reactions in man to vaccines containing tetanus and diphtheria toxoids vaccine gupta rk, chang ac, griffin p, rivera r and siber acyclovir and birth control gr in vivo distribution of radioactivity in mice after injection of biodegradable polymer microspheres containing clabeled tetanus toxoid vaccine ulanova m, tarkowski a, hahnzoric m acyclovir and birth control and hanson la the common vaccine adjuvant aluminum hydroxide upregulates accessory properties of human monocytes via an interleukindependent mechanism infect immun shi y, hogenesch h, regnier acyclovir and birth control fe and hem sl detoxification of endotoxin by aluminum hydroxide adjuvant vaccine edelman r new generation vaccines adjuvants for the future, in levine gcw, mm, acyclovir and birth control kaper jb and cobon gs eds marcel dekker, inc, new york, pp zinkernagel rm, ehl s, aichele p, oehen s, kundig t and hengartner h acyclovir and birth control antigen localization regulates immune responses in a dose and timedependent fashion a geographical view of immune reactivity immunol rev fearon dt seeking wisdom in innate acyclovir and birth control immunity nature fearon dt and locksley rm the instructive role of innate immunity in the acquired immune response science yip hc, karulin ay, tarylehmann m, hesse acyclovir and birth control md, radeke h, heeger ps, trezza rp, heinzel fp, forsthuber t and lehmann pv adjuvantguided type and type immunity infectiousnoninfectious dichotomy defines the class of acyclovir and birth control response f immunol kreuter j and speiser pp new adjuvants on a polymethylmethacrylate base infect immun eldridge jh, staas jk, meulbroek ja, tice tr and acyclovir and birth control gilley rm biodegradable and biocompatible poly dllactidecoglycolide microspheres as an adjuvant for staphylococcal enterotoxin в toxoid which enhances the level of toxinneutralizing antibodies infect immun ohagan acyclovir and birth control dt, jeffery h and davis ss longterm antibody responses in mice following subcutaneous immunization with ovalbumin entrapped in biodegradable microparticles vaccine nakaoka r, inoue y, acyclovir and birth control tabata y and ikada y size effect on the antibody production induced by biodegradable microspheres containing antigen vaccine tabata y, inoue y and ikada y acyclovir and birth control size effect on systemic and mucosal immune responses induced by oral administration of biodegradable microspheres vaccine quintanarguerrero d, allemann e, fessi h and doelker e preparation acyclovir and birth control techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers drug dev ind pharm vajdy m and ohagan dt microparticles for intranasal immunization adv acyclovir and birth control drug del rev singh m and ohagan d the preparation and characterization of polymeric antigen delivery systems for oral administration blind viagra adv drug del rev cui acyclovir and birth control z and mumper rj microparticles and nanoparticles as delivery systems for dna vaccines crit rev ther drug can syst gupta rk, singh m and ohagan acyclovir and birth control dt polylactidecoglycolide microparticles for the development of singledose controlledrelease vaccines adv drug del rev tamber h, johansen p, merkle hp and gander в formulation aspects of biodegradable polymeric microspheres for antigen delivery adv drug del rev panyam j and labhasetwar v biodegradable nanoparticles for drug and gene delivery to cells and acyclovir and birth control tissue adv drug del rev degen wg, jansen t and schijns ve vaccine adjuvant technology from mechanistic concepts to practical applications expert rev vaccines schijns ve immunological concepts of vaccine adjuvant activity commentary cur opin immun scholes pd, coombes aga, ilium l, daviz ss, vert m and davies mc the preparation acyclovir 10 500 lortab and birth control of sub nm poly lactidecoglycolide microspheres for sitespecific drug delivery ] control rel blanco md and alonso mj development and characterization of proteinloaded polylactidecoglycolide nanospheres acyclovir and birth control eur j pharm biopharm nguyen xc, herberger jd and burke pa protein powders for encapsulation a comparison of sprayfreeze drying and spray drying of darbepoetin acyclovir and birth control alfa pharm res thomasin c, merkle hp and gander в drug microencapsulation by plaplga coacervation in the light of thermodynamics parameters determining microsphere formation j pharm sci thomasin с, ho nt, merkle hp and gander в drug microencapsulation by plaplga coacervation in the light of thermodynamics overview and theoretical considerations } acyclovir and birth control pharm sci cleland jl and jones aj stable formulations of recombinant human growth hormone and interferongamma for microencapsulation in biodegradable microspheres pharm res singh m, kazzaz j, chesko j, soenawan e, ugozzoli m, giuliani m, pizza m, rappouli r and ohagan dt anionic microparticles are a potent delivery system for acyclovir and birth control recombinant antigens from neisseria meningitidis serotype b j pharm sci jung t, kamm w, breitenbach a, hungerer kd, hundt e and kissel t tetanus toxoid loaded acyclovir and birth control nanoparticles from sulfobutylated polyvinyl alcoholgraftpolylactide coglycolide evaluation of antibody response after oral and nasal application in mice pharm res kazzaz j, neidleman j, singh m, acyclovir and birth control ott g and ohagan dt novel anionic microparticles are a potent adjuvant for the induction of cytotoxic t lymphocytes against recombinant p gag from hiv acyclovir and birth control } control rel fessi h, puisieux f, devissaguet jp, ammoury n and benita s nanocapsule formation by interfacial polymer deposition following solvent displacement int } pharm acyclovir and birth control rr fessi h, puisieux f and devissaguet jp process for the preparation of dispersible colloidal systems of a substance in the form of nanocapsules eur patent peltonen l, koistinen p, karjalainen m, hakkinen a and hirvonen j the effect of cosolvents on the formulation of nanoparticles from lowmolecularweight polyllactide aaps pharm sci tech e wehrle p, magenheim в and benita s the influence of process parameters on the pla nanoparticle size distribution, evaluated by means of acyclovir and birth control factorial design eur } pharm biopharm niwa t, takeuchi h, hino t, kunou n and kawashima y preparations of biodegradable nanospheres of watersoluble and insoluble acyclovir and birth control drugs with — lactide glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior j control rel molpeceres j, guzman acyclovir and birth control m, aberturas mr, chacon m and berges l application of central composite designs to the preparation of polycaprolactone nanoparticles by solvent displacement } pharm sci acyclovir and birth control calvo p, remunanlopez c, vilajato jl and alonso mj development of positively charged colloidal drug carriers chitosan coated polyester nanocapsules and submicron emulsions coll polym sci acyclovir and birth control jung t, breitenbach a and kissel t sulfobutylated polyvinyl alcoholgraft polylactidecoglycolides facilitate the preparation of small negatively charged biodegradable nanospheres control rel ohagan dt, palin acyclovir and birth control kj and davis ss polybutylcyanoacrylate particles as adjuvants for oral immunization vaccine chauvierre c, labarre d, couvreur p and vauthier с novel polysaccharide decorated polyisobutyl cyanoacrylate nanoparticles pharm res major m, prieur e, tocanne jf, betbeder d and sautereau am characterization and phase behaviour of phospholipid bilayers adsorbed on spherical polysaccharidic acyclovir and birth control nanoparticles biochim biophys acta baudner вс, balland o, giuliani mm, von hoegen p, rappuoli r, betbeder d and del giudice g enhancement of protective efficacy acyclovir and birth control following intranasal immunization with vaccine plus a nontoxic ltk mutant delivered with nanoparticles infect immun singla ak and chawla m chitosan some pharmaceutical and biological acyclovir and birth control aspects an update} pharm pharmacol mcneela ea, jabbalgill i, ilium l, pizza m, rappuoli r, podda a, lewis djm and mills khg intranasal immunization with genetically acyclovir and birth control detoxified diphtheria toxin induces t cell responses in humans enhancement of th responses and toxin neutralizing antibodies by formulation with chitosan vaccine nagamoto t, hattori acyclovir and birth control y, takayama к and maitani y novel chitosan particles and chitosancoated emulsions inducing immune response via intranasal vaccine delivery pharm res vila a, sanchez a, acyclovir and birth control tobio m, calvo p and alonso mj design of biodegradable particles for protein delivery j control rel ilium l, jabbalgill i, hinchcliffe m, fisher an acyclovir and birth control and davis ss chitosan as a novel nasal delivery system for vaccines adv drug del rev pantarotto d, partidos cd, hoebeke j, brown f, kramer e, acyclovir and birth control briand jp, muller s, prato m and bianco a immunization with peptidefunctionalized carbon nanotubes enhances virusspecific neutralizing antibody responses chem biol cui z and mumper acyclovir and birth control rj coating of cationized protein on engineered nanoparticles results in enhanced immune responses int j pharm he q, mitchell a, morcol t and bell sj acyclovir and birth control calcium phosphate nanoparticles induce mucosal immunity and protection against herpes simplex virus type clin diagn lab immunol bisht s, bhakta g, mitra s and maitra a acyclovir and birth control pdna loaded calcium phosphate nanoparticles highly efficient nonviral vector for gene delivery int j pharm ohagan dt novel delivery systems for oral vaccines microparticles as oral vaccines ohagan dt, editor crc press, boca raton ohagan dt, ott gs and van nest g recent advances in vaccine adjuvants the development of acyclovir and birth control mf emulsion and polymeric microparticles mol med today moore a, mcguirk p, adams s, jones wc, mcgee jp, ohagan dt and mills kh immunization with a acyclovir and birth control soluble recombinant hiv protein entrapped in biodegradable microparticles induces hivspecific cd cytotoxic t lymphocytes and cd thl cells vaccine maloy kj, donachie am, ohagan dt and mowat am induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in polylactidecoglycolide microparticles immunology nixon df, hioe c, chen pd, acyclovir and birth control bian z, kuebler p, li ml, qiu h, li xm, singh m, richardson j, mcgee p, zamb t, koff w, wang cy and ohagan d synthetic peptides entrapped in microparticles can elicit cytotoxic t cell activity vaccine vordermeier hm, coombes ag, jenkins p, mcgee jp, ohagan dt, davis ss and singh m synthetic delivery system for tuberculosis vaccines immunological evaluation of the m tuberculosis kda protein entrapped in biodegradable plg microparticles vaccine kovacsovicsbankowski m and rock acyclovir and birth control kl a phagosometocytosol pathway for exogenous antigens presented on mhc class i molecules science scheicher c, mehlig m, dienes hp and reske к uptake of microparticleadsorbed protein antigen by bone marrowderived dendritic cells results in upregulation of interleukin alpha and interleukin pp and triggers prolonged, efficient antigen presentation eur j immunol acyclovir and birth control brayden dj and baird aw microparticle vaccine approaches to stimulate mucosal immunisation microbes infect florence at the oral absorption of micro and nanoparticulates neither exceptional acyclovir and birth control nor unusual pharm res vila a, sanchez a, janes k, 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